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Aluminum adjuvants have been used in vaccines for over 80 years in order to increase the immune response in vaccinated individuals. While the addition of aluminum adjuvants has been extremely successful, the success powered the adjuvants to be used in numerous vaccines without a proper understanding of their mechanisms of action. Advancements in medical understanding over the last 4-5 decades has resulted in researchers understanding the harsh reality of aluminum toxicity. Due to this, researchers have begun to delve into the actions and mechanisms of these adjuvants in an effort to enhance understanding of how they work. This review will discuss the importance of understanding the history of vaccination, the use and incredible success of aluminum adjuvants in vaccines, proposed mechanisms of action for aluminum adjuvants, aluminum toxicity levels, and future issues to be discussed regarding the safety of addition of aluminum adjuvants.

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